![]() clozapine, diclofenac, acetaminophen, omeprazole, reservatrol *, polydatin, phloretin *, cladosporin M01 LVQ/E267V/G415S/G1049E clozapine, diclofenac, acetaminophen, testosterone *, noresthisterone *, methoxyresorufin, ethoxyresorufin M02 LVQ/L86I/N319T/A964V clozapine, diclofenac, acetaminophen, norandrostenedione, methoxyresorufin, ethoxyresorufin, buspirone, amitriptyline, aripiprazole M05 LVQ/F81I/E267V/G415S clozapine, diclofenac, acetaminophen, methoxyresorufin, ethoxyresorufin M11 LVQ/E64G/F81I/E143G/E267V/G415S clozapine, diclofenac, acetaminophen, Testosterone *, norethisterone *, dextromethorphan, nifedipine, midazolam, 3,4-methylenedioxymethylamphetamine, estradiol, methoxyresorufin, ethoxyresorufin, buspirone, duloxetine, thioridazine, ondansetron, imatinib, omeprazole, rosiglitazone, paroxetine, norethisterone, resveratrol, dihydrobenzophenone, 17α-ethinylestradiol, bisphenol A, diethylstilbestrol, hexestrol, estriol, benzophenone-3, aldrin, testosterone, tramadol, imidazole, ketoconazole 9-10A R47C/V78A/K94I/P142S/T175I/A184V/F205C /S226R/H236Q/E252G/R255S/A290V/元53V verapamil, astemizole, LY294002 139-3 V78A/H138Y/T175I/V178I/A184V/ H236Q/ E252G/R255S/A290V/A295T/元53V androstenedione GVQ A74G/F87V/L188Q testosterone, amodiaquine, dextromethorphan, acetaminophen, 3,4-methylenedioxymethylamphetamine Following the above studies, BM3 libraries were designed with the aim of reaching the promiscuity of the major human drug-metabolizing P450s. ![]()
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